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Pen-style e-cigs have a number of advantages over cigalikes, but one of the most significant is that they can be refilled

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"In addition to containing varying levels of the addictive substance nicotine, they also contain other cancer-causing chemicals, such as formaldehyde, and as our study shows, flavoring chemicals that can cause lung damage." Each device was put into an artificial inhaler which drew on the e-cig for eight seconds at a time