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The increase in oxidative stress leads to these cells apoptosis which are related to altered bone formation and lower mineral density 50 , 51

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Therefore, further stratified analyses were performed on gender, whether women were menopausal or not, BMI and alcohol consumption, and baseline clinical data were divided into various subgroups, and Cox models were constructed separately, adjusting for other relevant influencing factors to clarify whether smoking was an independent influencing factor on the occurrence of HUA

9b, the effect of CSE on JAM1 was sufficiently compensated by vitamin C, while conversely that was abrogated by JAM1 knockdown