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Theorists and data analysts usually assume that causal effects are symmetric 13 meaning that if a unit increase in variable x produces a change of b units in variable y , then a unit decrease in x will result in a change of - b units in y 14

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The increase in MUC5AC expression correlated with reduced expression of the basal cell marker KRT5 as well as the club cell marker SCGB1A1 , suggesting PG/VG aerosols possibly shift the differentiation of basal and club cells to goblet cells