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Aleniglipron activates the GLP-1 receptor through a small molecule binding mechanism distinct from the orthosteric peptide binding site used by native GLP-1 and peptide analogs

En este contexto, los agonistas del receptor del pptido-1 similar al glucagn (GLP-1 RA) han surgido como una opcin teraputica prometedora, debido a sus beneficios en el control de peso y la mejora de la resistencia a la insulina

Diabetes, Obesity & Metabolism , 27 (3), 14441455

These agents provide multiple benefits, including weight reduction, cardio-renal protection, improved heart failure symptoms and hepatic steatohepatitis, and overall reduced mortality [2,3,4,5,6,7,8,9]