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It was previously demonstrated that the exposure of lung cells at the ALI to whole cigarette smoke was a better model to recapitulate levels of nicotine/cotinine measured in the sputum of smokers than submerged in vitro models using cigarette smoke condensates 56

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Califano, Jr., New York: PublicAffairs, 2004 Anti-Smoking Ads Califano Dares Tobacco Industry News article by Maitland Zane San Francisco Chronicle January 12, 1978 I dont think there needs to be any concern about that, and nobody need fear the facts about tobacco use