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The connection is indirect: the medication drives the fat loss, and the fat loss generates the oxidative stress that glutathione is designed to neutralise

doi:10.1021/acs.bioconjchem.4c00545

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By attaching a larger molecule, like a polyethylene glycol (PEG) chain (a process called PEGylation), scientists can make the peptide too large to be easily filtered by the kidneys and can also sterically hinder the approach of degrading enzymes