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There are also higher-dose versions of these medicines, such as Wegovy (semaglutide) and Zepbound (tirzepatide), that have been recently approved for weight loss alone

It can cause pain while walking, slow-healing wounds, and, in severe cases, critical limb ischemia, a condition in which severely impaired blood flow can lead to tissue damage and the need for amputation

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No one warned them, Hey, youre going to have all this loose, hanging skin afterwards. In extreme cases, she adds, they almost feel a little bit deformed because of the skin. With next-generation GLP-1s, like an oral version of Wegovy and injectable retatrutide, poised to launch as early as 2026, body-contouring procedures will continue to skyrocket, says Darren Smith, MD, a board-certified plastic surgeon in New York City