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These stimuli activate airway epithelial cells and alveolar macrophages, leading to the release of pro-inflammatory mediators (e.g., TNF-, IL-1, IL-6) and chemokines (e.g., CXCL8, LTB4) (Figure 1), which recruit neutrophils into the airway wall, ultimately driving the inflammatory response in small airways ( + /CD8 + T lymphocytes

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