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Clinical trials analysing a class of cancer medication called small-molecule tyrosine kinase inhibitors, which targets a family of proteins that are mutated in many types of cancer, showed that never-smokers, individuals with adenocarcinoma, women and people with east Asian ancestry were more likely to respond well to the drugs than people with a history of smoking 2

Less is known about the relationship between vaping and smoking among individuals with moderate levels of psychological distress (MPD), a group whose members may not experience serious mental illness but still endorse higher rates of mental healthcare utilization, impairment, substance use, and other risks compared to those with no/low psychological distress 24