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For example, argininosuccinate synthase 1 (ASS1), and ornithine transcarbamylase (OTC) expression status have been used to identify patients who are likely to benefit from arginine-targeted therapies, including arginine deiminase and PEG-arginase therapies, which are showing great promise in improving the sensitivity of a subset of lung and liver tumors to standard-of-care therapies (1820)

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