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Interestingly, using a cross-over analysis we found that exposure to ETS during the 1st trimester (the 1st trimester only, both the 1st and 2nd trimester, both the 1st and 3rd trimester marginal significantly and the all three trimesters of pregnancy significantly) increased the risk of preschoolers obesity (see Table 3), which suggests that the 1st trimester might be the critical period for the detrimental effect of prenatal ETS exposure on childrens obesity (45)

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