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COVID19nAChRsCNS It is of interest to note that SARSCoV2 may enter the central nervous system (CNS) through the bloodstream, via the olfactory nerve across the cribriform plate, by disrupting the bloodbrain barrier (BBB) or infecting the peripheral nerves [43, 67, 68, 69], where it may cause ACE2 downregulation and a local inflammatory response referred to as neuroinvasion, a common feature of coronaviruses [70]

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