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In mice, GPX4 knockdown leads to age-dependent neurodegenerative changes and neuronal loss, which can be exacerbated by dietary deficiency of vitamin E (a ferroptosis inhibitor) 61

Once ingested, pyridoxine is converted into its active form, pyridoxal phosphate (PLP), which plays a pivotal role in various metabolic processes, including: Amino Acid Metabolism: PLP actively participates in the metabolism of amino acids the building blocks of proteins

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[ref][ref][ref] Homocysteine goes down the transsulfuration pathway to form cysteine: Another path that homocysteine can take is to be converted to cysteine through a two-step process in the transsulfuration pathway