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By comparing model 1 and model 2, the current study observed a weakening of statistical significance and effect sizes across 11 brain regions when BMI was added, suggesting a possible, but not definitively proven, mediating effect of BMI in the association between the increase in smoking pack years and reduced brain volumes

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In 1986, Lorillard had sales of nearly $1.6 billion, excluding taxes, turning out over 47 billion cigarettes for an 8.1 percent share of the U.S

Its not known whether similar issues have occurred since then