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Facts Design: Two-group pragmatic, multicenter, unblinded randomized control trial 2 Participants were randomized to receive second generation refillable EC product (Aspire One Kit) or NRT (patch, gum, lozenge, nasal spray, inhalator, mouth strip, and microtabs) for smoking cessation treatment combined with weekly in-person behavioral support/counseling in each treatment group Primary outcome: sustained abstinence for 12 months by self-report validated with expired carbon monoxide levels Secondary outcome: abstinence at 4, 26, and 2652 weeks from target quit date, carbon monoxide validated reduction in smoking by 50%

Nicotine has short-term pharmacological effects, including increased heart rate and blood pressure

18, 2019, [73] Michael F

Studies show that combining multiple approaches, such as using NRT alongside behavioral therapies, significantly boosts quit rates