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They require proper patient selection, careful dose titration, side effect monitoring, nutritional counseling to prevent lean mass loss, and long-term follow-up planning

Semaglutide and Tirzepatide are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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The absence of approved pharmaceutical versions means all Retatrutide comes from research peptide manufacturers, making supplier selection particularly important