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Each tobacco product contains different amounts of nicotine, but on average, a typical cigarette contains about 10-15 mg, with the average smoker inhaling approximately 1-2 mg of nicotine

In addition, this tobacco use is also strongly associated with leukoplakia a precancerous lesion of the soft tissue in the mouth that consists of a white patch or plaque that cannot be scraped off

Notably, a proof-of-principle, randomized, double blind, placebo-controlled study of GS-9450 (selective inhibitor of caspases 1, 8, and 9) suggests that reducing hepatocellular apoptosis may be a valuable therapeutic strategy in patients with NASH (39)

Treatment planning Understanding the type of nicotine dependence helps inform appropriate treatment, including counseling, medication, or life management difficulty interventions