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It demonstrates our commitment to enabling the development of safe and effective product innovations that may help smokers quit combustible cigarettes and improve their health. This guidance includes several innovations in the regulatory pathway for NRT drug products

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ESOPHAGUS (FOOD PIPE) The nicotine and other harmful chemicals in tobacco smoke can weaken the lower esophageal sphincter (LES), a muscular ring that separates the esophagus from the stomach

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