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Below is a listing of clinical signs by the system affected: Gastrointestinal: vomiting, hypersalivation, diarrhea, abdominal pain/discomfort Cardiovascular: hypertension, cardiac arrhythmias Neurologic: ataxia, weakness, mydriasis, seizures Pulmonary: initial tachypnea followed by respiratory depression Diagnosis The diagnosis is often made possible by a history inclusive of exposure to nicotine and is often suggested by the combination of clinical signs with their acute onset