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[61] [62] Tobacco smoke is a complex mixture of over 7,000 identified chemicals, of which 250 are known to be harmful, at least 69 cause cancer, and 98 are known to have specific toxicological properties

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The researchers analyzed 1,366 lung transplants from 1,291 donors that were performed among 1,352 recipients at Cleveland Clinic between January 2007 and February 2020

Participants were asked about their smoking behaviors during nine periods across their lives, beginning with before they reached their 15 th birthday until after they reached the age of 70 (for the older participants)