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The pollutant of most concern from wildfire smoke is fine particulate matter (PM 2.5), the Minnesota Department of Health explains

A growing body of evidence indicates that oxidants and electrophiles are among the principal mediators involved in the initiation and progression of several vascular and cerebrovascular diseases, such as chronic inflammatory disease, stroke, neurodegenerative diseases such Alzheimers, Parkinsons and amyotrophic lateral sclerosis (ALS), and aging [39,40,41,42,43,44]

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