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35 In the brain, nicotine leads to habitual use through the nicotine receptor, and in the kidney, nicotine induces oxidative stress because nicotine is excreted by glomerular filtration and tubular secretion

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TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase

Musically, it is indebted to the likes of Mazzy Star, Cowboy Junkies and Beach House, while lyrically there is also a nod to the poetry of Richard Brautigan