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The mechanism of the antidepressant effect of exercise is not precisely known, and is likely multi-factorial, with alterations in neurotransmitters, inflammatory cytokines, neuroendocrine pathways, dopamine processing, oxidative stress, neuroplasticity, reward processing, body image, self-efficacy, functional independence, and many other pathways likely operative [455] The dose-response characteristics, such as adequate doses for aerobic exercise [193] and appropriate intensity for PRT [447], indicate that its benefits stem from biological mechanisms rather than merely the effects of attention or socialization

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The lower court issued a decision vacating the FDAs graphic cigarette health warning regulations, saying they violated free speech protections under the First Amendment

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