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In rats, LTP is induced by tetanic stimulation of the hippocampus, which in turn generates translocated pkc activity two-fold at the cell membrane, a required context for LTP consummation (Lovinger and Routtenberg, 1988), with pkc activity being required for multiple steps in memory consolidation (Sossin et al., 1994), while spatial learning effectively causes a redistribution of pkc (Olds et al., 1990)
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