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First, we revealed that pre-infusion CAR T cell products from LTR have an altered immunometabolic signature acquiring features of memory T cells, which is associated with improved anti-tumor efficacy and persistence, including increased OXPHOS, markers of fatty acid oxidation, and PPP activities (Fig

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It does not slot neatly into an endocrine signaling cascade

Methylene blue pretreatment inhibited S-nitroso-L-cysteine and sodium nitroprusside induced cyclic guanosine monophosphate accumulation by 51% to 100%, but S-nitroso-3-mercaptoproprionic acid mediated responses were not altered by methylene blue