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After the initial 36 weeks, participants lost 21.1% of their body weight After the following 52 weeks, the tirzepatide group lost another 6.7% of their body weight, while the placebo group regained 14.8% Through the 88-week study, the tirzepatide group lost 26% of their body weight Tirzepatide had a similar safety profile in SURMOUNT-3 and SURMOUNT-4 as its previous trials, most commonly citing mild-moderate gastrointestinal issues

Adequate intake of zinc and iron reduces the absorption of cadmium, while calcium, selenium, iron and calcium reduce the absorption of potassium