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Statistical significance was determined by two-tailed unpaired t -test

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Birben E, Sahiner UM, Sackesen C et al (2012) Oxidative stress and antioxidant defense

However, various limitations of these two biomarkers, including low sensitivity and specificity, delayed rise in plasma because of functional reserve, and extrarenal clearance, demand for novel renal biomarkers to early detect and monitor drug-induced nephrotoxicity with high specificity and sensitivity