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Only one out of the four prospective studies reported a significant protective effect of Se on the development of hypertension while the remaining studies found no association between Se and hypertension

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Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]

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