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This loss of high affinity binding could be reversed by the overexpression of G s in the all G cell line, consistent with G s allosterically influencing the affinity of GLP-1, exendin-4 and oxyntomodulin, with much more limited effect on exendin-P5 (Figure 7A)

Finally, they were combined, concentrated and freeze-dried to obtain 13.6 g of the finished product, and the purity determined by HPLC was greater than 98%, indicating that this technical condition can be directly scaled up for production

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