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A placebo-controlled RCT investigated TAK-071 , a muscarinic acetylcholine M1 PAM, as a treatment to improve gait function in 54 participants with PD with cognitive impairment assessed a cognitive composite score as a secondary endpoint and found a significant improvement [163]

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AD patients have increased glutamate and one of the ways the BBB is disrupted in AD patients is with reduced GLUT1 expression, but the GLUT1 stimulator ceftriaxone has been shown to improve hippocampal memory and synaptic plasticity impairment in AD model mice [138, 139]

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