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As key regulators of intestinal homeostasis, normal microbiota maintain the integrity of the intestinal epithelial barrier and immune tolerance through their metabolic products

Additionally, tirzepatide may affect the absorption of oral medications due to delayed gastric emptying, which is relevant for drugs with narrow therapeutic windows

Once released, DA binds to and activates dopamine receptors located on the postsynaptic membrane

The STEP 4 withdrawal trial showed that most participants regained approximately two-thirds of lost weight within one year of discontinuation, confirming that semaglutide treats obesity chronically rather than curing it