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4 Discussion The improvement of semaglutide on obese individuals is significant, and the main mechanism of this type of GLP-1RA is to stimulate GLP-1R, triggering activation of several metabolic pathways involved in insulin secretion, lipid metabolism, energy expenditure, cell survival, anti-apoptotic signaling, and oxidative stress prevention in tissues such as the pancreas, central nervous system, heart, muscles, kidneys, and intestines ( We found that intraperitoneal injection of 100 g/kgbw of semaglutide every other day significantly improved the abnormal weight gain induced by a high-fat diet, reduced the proportion of white adipose tissue in the groin and epididymis

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Patients with certain conditions, including MEN2, medullary thyroid carcinoma, or pregnancy, may not be eligible

Funding statement Departmental only