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Obesity promotes a chronic, low-grade inflammatory state through adipokine release and up-regulation of cytokines such as tumor necrosis factor (TNF), interleukin-17 (IL-17), and IL-6, while mechanical stress at entheseal sites and reduced physical activity exacerbate musculoskeletal symptoms

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Balmus IM, Ciobica A, Antioch I, Dobrin R, Timofte D (2016) Oxidative stress implications in the affective disorders: main biomarkers, animal models relevance, genetic perspectives, and antioxidant approaches

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