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Both IGF-1R and insulin receptor activation promote anabolic processes in various tissues so it is reasonable to assume that when insulin binds to IGF-1R and IGF-1 binds to the insulin receptor, they induce the anabolic processes usually associated with these receptors binding their main ligands

Neurobiol Dis 20(2):608614 Zhan B, Zhu Y, Xia J, Li W, Tang Y, Beesetty A, Ye J-H, Fu R (2022) Comorbidity of post-traumatic stress disorder and alcohol use disorder: animal models and associated neurocircuitry

These responses are coordinated by complex intracellular signaling pathways mediated by abscisic acid (ABA), Ca 2 , and mitogen-activated protein kinases (MAPKs), which modulate both redox homeostasis and cellular adaptation (Liu et al

Conventional therapies include corticosteroids, immunomodulators, vitamins, phototherapy, surgery, and laser therapy