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The main reason CLA Tonalin is an excellent ally in weight-loss programs is its partitioning action on body composition, which is responsible for a significant reduction in fat mass relative to muscle mass

Additionally, the expression of mRNA and protein for both 25-hydroxylases (CYP2R1 and CYP27A1), 1--hydroxylase (CYP27B1), and VDR were downregulated, but that of 24-hydroxylase (CYP24A1) was significantly upregulated in the liver of HFD-fed mice compared to those in controls (Fig

(This helps explain the somewhat counterintuitive protective effect of obesity against bone fractures and osteoporosis.) This makes strength training and aerobic exercise even more crucial