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A randomized controlled trial showed that GLP-1RAs prevents the decline of cerebral metabolic rate for glucose (CMRglc) in AD, and GLP-1RAs may increase the expression of glucose transporters (e.g., GLUT1) at the blood-brain barrier (BBB) (Mullins et al., 2019)

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US Holds Largest Share in North America Driven by High Healthcare Spending The US GLP-1 receptor agonist market held the largest share in North America in 2025 due to its patient population, favorable regulatory environment, and high healthcare spending per capita

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