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This multimodal approach leverages the strengths of each intervention while mitigating their individual limitations
Indeed, owing to its ability to activate the tolerogenic pathway of tryptophan catabolism via the immunoregulatory enzyme indoleamine 2,3-dioxygenase 1 (Puccetti and Grohmann, 2007), T1 specifically potentiates immune tolerance in the lung, breaking the vicious circle that perpetuates chronic lung inflammation in response to a variety of infectious noxae (Romani et al., 2006)
The evolution of metabolic science isn't just about discovering new molecules
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