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Indeed, the reversible one-electron reduction of Cu(II) does occur, as exemplified by the thiosemicarbazone complex of Cu(II) in the elesclomol [330, 331] (Table 3)

Active malignancy requires careful evaluation Patients with active or recent malignancy require thorough clinical evaluation before initiation

After the infusion, the IV is disconnected, and the site is cleansed

In general cyanocobalamin isn't retained as long as hydroxocobalamin so maintenance dosing tends to be more frequent - think in the states they tend to do loading doses as daily for one or two weeks followed by weekly for a few months and then monthly