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CagriSema vs Tirzepatide (REDEFINE 4): strong weight loss, but an important endpoint miss Novo Nordisk has announced headline results from the open-label phase 3 REDEFINE 4 trial comparing CagriSema (cagrilintide + semaglutide) vs tirzepatide 15 mg in obesity

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3,5 Whereas injectable semaglutide achieved 15% mean weight loss at 68 weeks in the Semaglutide Treatment Effect in People with obesity (STEP-1) study, it requires subcutaneous administration