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Studies have shown that impaired levels of insulin and an increase in insulin resistance lead to increased adipose lipolysis and FFA release into the circulation and their enhanced hepatic uptake, subsequently causing fat accumulation in the liver (Zhong et al., 2012

In another study presented by Ingbers group in 2022 (174), environmental enteric dysfunction (EED), a chronic inflammatory condition of the intestine, was recapitulated on a microfluidic device lined with organoid-derived intestinal epithelial cells from EED patients

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