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Studies investigating the regulation of ion channels relevant to mitochondrial iron transport and cardiac dysfunction due to iron overload have demonstrated that the MCU facilitates the transport of Fe2 + into the mitochondria, while Mfrn2 may serve a regulatory function in this process [11]

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The Cochrane Risk of Bias 2 (RoB 2) tool (Sterne et al., 2019) was applied to assess the quality of the randomized controlled trials (RCTs) included in this review