Starting in December 2022, Mounjaro began to pull back some of its marketing (including transitional assistance) 2 and focused on diabetes patients as opposed to all patients which included weight loss patients
Retatrutide is a novel triple receptor agonist peptide developed by Eli Lilly that simultaneously targets the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R)
The drug companies believe that hitting more receptors induces better weight-loss effects, which does appear to be true, but when it comes to what this is doing across different immune populations, downstream signaling can be completely changed by adding on these extra agonists, she says
Why It Pairs So Well With GLP-1 Agonists GLP-1 agonists like Retatrutide create a caloric deficit through multiple routes: appetite suppression, slowed gastric emptying, and (in Reta's case) glucagon receptor agonism that drives additional energy expenditure