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SOCS proteins bind JAKs or their receptors and act by (i) abolishing the kinase ability of JAK, (ii) abolishing the ability of JAK to bind to the receptor, (iii) blocking STATs from being recruited to the receptor, and (iv) mediating the ubiquitination of JAKs and STATs for degradation (124)

Bacterial strains, plasmids, media and growth conditions The bacterial strains and plasmids used in this study are presented in Table 1

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In addition, these changes cause a reduction of cerebral blood flow (CBF) and synaptic dysfunction with the development of neurodegeneration and cognitive impairment (Kamat et al