Furthermore, the evidence remains inconsistent, as the potential benefits of TRT are often accompanied by other iatrogenic effects, including erythrocytosis, benign prostatic hyperplasia, gynecomastia, and an increased risk of prostate cancer [178, 179]
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Primary Endpoint Disease-free survival (DFS) Secondary Endpoints: Loco-regional failure-free survival (LRFS), distant metastasis-free survival (DMFS), overall survival (OS), pathological complete response (pCR), R0 resection rate, toxicity, and post-surgical complications Background Locally advanced rectal cancer (LARC) with threatened or involved circumferential resection margins (CRM) represents a high-risk group for recurrence and poor outcomes
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