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A 2025 Bayesian network meta-analysis of 48 RCTs covering 27,729 participants compared GI adverse events across the major GLP-1 RAs.[1] Tirzepatide showed the highest risk of nausea and diarrhea among the agents studied

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The serine synthesis pathway (SSP) utilizes the glycolytic intermediate 3-phosphoglycerate (3-PG), which is converted by phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) into serine [24]

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