Unlike corticosteroids or broad immunosuppressants, KPV does not appear to suppress immune function globally its NF-kB inhibition is targeted and does not eliminate the immune response, only attenuates the pro-inflammatory cascade
(Source 2) Broccoli and other members of the cruciferous family, including kale, collard greens, cabbage, and cauliflower, are rich in sulfur compounds (like sulforaphane), which support detoxification and are cancer-protective
Cellular iron uptake (via transferrin receptor TFRC), storage (in ferritin), and release (via ferritinophagy mediated by NCOA4) are tightly regulated ( 2.1.2 Transcriptional control by Nrf2 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of the antioxidant response and a central mediator of cellular defenses against ferroptosis ( Nrf2 activation upregulates key ferroptosis defense components ( - subunits (SLC7A11 and SLC3A2), promoting cystine uptake and GSH biosynthesis ( However, in the context of chronic diseases like asthma, sustained or dysregulated Nrf2 activation can exhibit paradoxical, pro-ferroptotic effects ( 2.2 Regulation of iron metabolism: IRP2, ferritinophagy, and systemic influences Iron availability, particularly labile Fe 2+ , is indispensable for lipid peroxidation and the execution of ferroptosis ( Key regulatory targets include: Transferrin Receptor 1 (TfR1), whose mRNA is stabilized upon IRP2 binding to 3 UTR IREs to enhance iron uptake
Ishikawa H, Takaki A, Tsuzaki R, et al
