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The combination of cilofexor and firsocostat achieved a significant decrease in the ML NASH CRN fibrosis score (p = 0.040) and a change in biopsy area from F3-F4 fibrosis patterns to F2

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Degnan, P

We interpret the clinical and mechanistic data obtained for different agents that enable weight loss and glucose control for the treatment of obesity and type 2 diabetes mellitus, respectively, by activating or blocking GIPR signalling, including the GIPRGLP1R co-agonist tirzepatide, as well as the GIPR antagonistGLP1R agonist AMG-133