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Additionally, the fed state typical of evening hours may reduce absorption efficiency compared to morning fasted dosing

Seek urgent same-day assessment or call 999 for emergency care if experiencing: Severe chest pain Severe shortness of breath Fainting or collapse Acute or rapidly worsening neurological deficits (such as new limb weakness, sudden gait disturbance, or bladder/bowel dysfunction) Persistent or worsening anaemia symptoms despite treatmentincluding breathlessness, chest discomfort, palpitations, or extreme fatigueshould trigger medical review

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It reliably raises serum B12 levels, resolves megaloblastic anemia, and, when started before irreversible damage, can reverse neurological symptoms