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Discontinuation, regain, and reinitiation (class-level, semaglutide / tirzepatide) Budini 2026 ( eClinicalMedicine ) pooled regain curve: asymptotic maximum regain 75.3% of lost weight, half-life about 23 weeks, so roughly 60% of the loss returns by 12 months and about 40% is still held at a year

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However, the clinical significance of TMAO generation from L-carnitine supplementation in humans remains under active investigation, and there is currently no official regulatory warning from the MHRA or EMA specifically prohibiting its use on these grounds