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Although these differences were not clinically significant, the decision of administering dapalgiflozin to cirrhotic patients should be individually assessed because the long-term safety profile and efficacy have not been specifically studied in this population.81 Caution should be even greater when hepatic dysfunction is combined with renal impairment

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Predispositions in appetite and metabolic pathways influence baseline susceptibility, but clinical response depends on dose, timing, overall health, and individual adaptation